The team "Muscle and Pathologies" has been created in 2007 by INSERM and University Joseph Fourier – Grenoble, and is part of the "Grenoble Institute of Neuroscience".
Three axes of development
Understanding the function of this complex, and its targeting to the triad is necessary for the understanding of the pathophysiological mechanisms and the development of new therapies. To reach this purpose, the following axes are developed in the team:
We study the traffic of triad's proteins, the formation of the calcium release complex and the function of proteins of the calcium release complex in the formation of triads, in interaction with other elements like microtubules.
Pathophysiological mechanisms in myopathies
We identify the pathophysiological mechanisms resulting of mutations in a protein of the calcium release complex, thanks to the development and characterization of cellular or animal models. This allow us to understand the function of proteins involved in the complex, and the pathologies related to their alteration.
We are working on the development of treatments to correct the mutations resulting in congenital myopathies, with a focus on RyR1 mutation resulting in Central Core Disease.